As centers for population, infrastructure and economic activities, cities are key contributors to global emissions of greenhouse gases (GHG) and short-lived climate pollutants (SLCP) as well as key hot spots of climate change impacts and vulnerabilities. Understanding the processes and interlinkages of climate science, emissions, impacts, risks and vulnerabilities are central for co-producing strategies and alternatives to adapt to and mitigate climate change. The science of cities can guide the reduction of GHG and SLCP emissions, climate vulnerability, differential risks and help improve resilience. The analysis of social processes driving the construction and reconstruction of urban space, of urban form, design, typology, and policies are also key considerations. Contributions to better understanding the science and practice of cities in the context of climate change have expanded significantly in recent years. However, there are few forums creating opportunities to assess these contributions. The Theme 2 Plenary creates a platform to create an interactive dialogue on these issues incorporating scientific, policy, and practitioner’s knowledge.